Somatotropin, also known as human growth hormone (HGH), is a hormone produced by the pituitary gland in the brain.

Indications and contraindications of Somatotropin are important factors to consider when evaluating its usage. Somatotropin, also known as growth hormone, is a natural hormone produced by the pituitary gland that plays a vital role in various bodily functions.

One of the key indications for using Somatotropin is in individuals with growth hormone deficiency (GHD). GHD can occur due to problems with the pituitary gland or hypothalamus, leading to stunted growth and development. Somatotropin therapy can help stimulate linear growth, increase muscle mass, and improve bone density in these individuals.

Furthermore, Somatotropin has been approved for the treatment of several other medical conditions. It is commonly used for the management of Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, and short bowel syndrome among others.

However, despite its therapeutic benefits, Somatotropin also has certain contraindications that need to be considered. Individuals with active malignancy, such as cancer, should not use Somatotropin due to its potential to promote tumor progression. Additionally, patients with acute critical illness, severe respiratory impairment, or those undergoing surgery should avoid Somatotropin therapy.

In conclusion, understanding the indications and contraindications of Somatotropin is essential for safe and effective use. While it can offer numerous benefits in treating growth hormone deficiency and certain medical conditions, careful evaluation and consideration of contraindications are crucial before initiating Somatotropin therapy.

Indications and Contraindications of Somatotropin

Indications and Contraindications of Somatotropin


Somatotropin, also known as human growth hormone (HGH), is a naturally occurring hormone in the body that plays a crucial role in growth, cell regeneration, and maintenance of various bodily functions. It is produced by the pituitary gland and is essential for proper development and functioning of organs and tissues.


Somatotropin is indicated for the following conditions:

  • Growth Hormone Deficiency: Individuals with inadequate production of somatotropin may require supplementation to promote normal growth and development.
  • Short Stature: Children who are significantly shorter than their peers due to growth hormone deficiency or other medical conditions may benefit from somatotropin therapy.
  • Turner Syndrome: Girls with Turner syndrome, a genetic disorder characterized by the absence or incomplete development of the X chromosome, often have growth hormone deficiency and can benefit from treatment with somatotropin.
  • Chronic Renal Insufficiency: Somatotropin therapy can help stimulate growth in children with chronic renal insufficiency, a condition where the kidneys do not function properly.
  • Prader-Willi Syndrome: This rare genetic disorder causes poor muscle tone, delayed development, and excessive hunger. Somatotropin can help improve growth and body composition in individuals with Prader-Willi syndrome.


Somatotropin is contraindicated in certain situations:

  • Active Malignancy: Individuals with active malignancies, such as tumors or cancer, should not receive somatotropin therapy due to its potential to promote tumor growth.
  • Allergy or Hypersensitivity: Patients with known allergies or hypersensitivity to somatotropin or any of its components should avoid its use.
  • Severe Respiratory Impairment: Those with severe respiratory impairment, such as obstructive sleep apnea, should exercise caution when considering somatotropin therapy due to the risk of worsening their condition.
  • Acute Critical Illness: Somatotropin is not recommended for individuals in acute critical illness, as it may interfere with their recovery process.


Somatotropin is a valuable therapeutic agent that can significantly improve the quality of life for individuals with specific medical conditions. However, its use should always be carefully evaluated and prescribed by healthcare professionals, taking into account the indications and contraindications, as well as individual patient characteristics and needs.

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