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Letrozole: Description of the Drug

Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. As an aromatase inhibitor, it works by decreasing the levels of estrogen in the body, which can help slow or stop the growth of certain types of breast tumors that require estrogen to thrive.

Mechanism of Action

The description of the drug highlights its role in inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens. By blocking this process, letrozole significantly reduces estrogen production, leading to lower https://letrozolebuy.com/prod/letrozol-1-a-pharma-25-mg/ circulating estrogen levels. This effect is particularly beneficial for patients whose cancer growth is stimulated by estrogen.

Indications

Letrozole is commonly indicated for:

  • Adjuvant treatment of early-stage breast cancer in postmenopausal women.
  • Treatment of advanced breast cancer in patients who have progressed on tamoxifen therapy.
  • Off-label use in fertility treatments for women with polycystic ovary syndrome (PCOS).

Dosing and Administration

The standard dosage of letrozole is 2.5 mg taken orally once daily. It can be taken with or without food, and should be continued for as long as prescribed by a healthcare professional, typically up to five years in the adjuvant setting.

Side Effects

  • Hot flashes
  • Joint pain or stiffness
  • Fatigue
  • Nausea
  • Bone thinning (osteoporosis)

Contraindications and Precautions

Patients considering letrozole should inform their healthcare provider of any existing health conditions. Contraindications include:

  • Pre-menopausal status
  • Severe liver impairment
  • Known hypersensitivity to letrozole or any of its components

Women who are pregnant or breastfeeding should avoid using this medication due to potential risks to the fetus or nursing infant.

Conclusion

The description of the drug letrozole underscores its importance in managing hormone-sensitive breast cancer. Through its unique mechanism of action, it continues to be a crucial option for many postmenopausal women battling this disease.

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